Regulation of the tissue specificity of an enzyme by a cis-acting genetic element: evidence from interspecific Drosophila hybrids.
نویسندگان
چکیده
Homologous genes for alcohol dehydrogenase (alcohol:NAD+ oxidoreductase, EC 1.1.1.1) are expressed in qualitatively different patterns during the development of two closely related species of Hawaiian Drosophila. In interspecific hybrids, each parental structural allele is expressed according to the developmental program characteristic of the species from which it is derived. This provides strong evidence for a cis acting control element.
منابع مشابه
Tissue-specific expression phenotypes of Hawaiian Drosophila Adh genes in Drosophila melanogaster transformants.
Interspecific differences in the tissue-specific patterns of expression displayed by the alcohol dehydrogenase (Adh) genes within the Hawaiian picture-winged Drosophila represent a rich source of evolutionary variation in gene regulation. Study of the cis-acting elements responsible for regulatory differences between Adh genes from various species is greatly facilitated by analyzing the behavio...
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 76 9 شماره
صفحات -
تاریخ انتشار 1979